Although it is expected that the last phases of this process must be tightly regulated since it results in cell death, the signaling pathways involved in this induction remain ill defined. This Article First Published on January 28, doi: Classifications Mechanisms of Signal Transduction. To whom correspondence may be addressed: Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Request Permissions. Journal of Lipid Research.

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In support of this notion, we showed that DLK expression was restricted to the granular layer in situ. This Article First Published on January 28, doi: View this article with LENS.

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Prev Next Table of Contents. Articles by Germain, L.

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Related Content Load related web page information. Although it is expected that the last phases of this process must be tightly regulated since it results in cell death, the signaling pathways involved in this induction remain 800 defined.

Search for related content. Moreover the expression of wild-type DLK in keratinocytes stimulated transglutaminase activity and the consequent formation of the cornified cell envelope, while a kinase-inactive variant of DLK did not. Classifications Mechanisms of Signal Transduction. Together these results identify DLK as a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification.

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Google Scholar Articles by Robitaille, H. We now report that a single kinase, the mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase DLKacts in the epidermis to promote the terminal differentiation of human keratinocytes. Abstract In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum. Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in this journal Similar articles in Web of Science Similar articles 800 PubMed Download to citation manager Request Permissions.

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In addition, cultured keratinocytes infected with a recombinant adenovirus expressing DLK exhibited morphological and biochemical changes, including a suprabasal localization, altered cell shape, compacted cytoplasm, DNA 80000, and the up-regulation of filaggrin, that are reminiscent of a terminally differentiated phenotype. To whom correspondence may be addressed: In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum.